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3d silicon probes  (NeuroNexus Technologies)


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    NeuroNexus Technologies 3d silicon probes
    Illustration of exploration volume and significant volume in various <t>3D</t> electrode arrays. (A) Illustration of the concept of exploration volume and significant volume with a simple cubic electrode array. For better illustration, the electrode array in 3D is projected <t>to</t> <t>2D.</t> Black dots indicate electrodes, and black squares indicate electrodes, with their sensing radius of signals, i.e. 75 μm, in light blue. Union of light blue area and darker blue is defined as exploration volume. Intersection area with at least from 4 depicted in dark blue, which is defined as significant volume. Exporation volume increases while the electrode pitch increases, i.e. 45 μm to 100 μm. But significant volume decreases while the electrode pitch increases, i.e. 100 μm to 45 μm. (B) 5 types of 3D structures are proposed, i.e. simple cubic (SC), body-centered cubic (BCC), face-centered cubic (FCC), hexagonal, and tetrahedron. (C) Exploration volume increases in all types of 3D electrode arrays. Note that the linear array (Neuropixels-like) reaches peaks with electrode pitch of 100 μm. (D) Significant volume of all 3D electrode arrays dramatically increases and reaches peaks at electrode pitch of 85-100 um but decreases afterwards. Note that the linear array (Neuropixels-like) reaches the peak at electrode pitch of 45 μm.
    3d Silicon Probes, supplied by NeuroNexus Technologies, used in various techniques. Bioz Stars score: 97/100, based on 2508 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/3d+silicon+probes/Silicon+Neural+Probe+%2F+Silicon+Microelectrode+Array/bio_rxiv__2025__03__30__645752-25-1-15
    Average 97 stars, based on 2508 article reviews
    3d silicon probes - by Bioz Stars, 2026-10
    97/100 stars

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    1) Product Images from "Real-time spike sorting with 3D neural probe and triangulation localization"

    Article Title: Real-time spike sorting with 3D neural probe and triangulation localization

    Journal: bioRxiv

    doi: 10.1101/2025.03.30.645752

    Illustration of exploration volume and significant volume in various 3D electrode arrays. (A) Illustration of the concept of exploration volume and significant volume with a simple cubic electrode array. For better illustration, the electrode array in 3D is projected to 2D. Black dots indicate electrodes, and black squares indicate electrodes, with their sensing radius of signals, i.e. 75 μm, in light blue. Union of light blue area and darker blue is defined as exploration volume. Intersection area with at least from 4 depicted in dark blue, which is defined as significant volume. Exporation volume increases while the electrode pitch increases, i.e. 45 μm to 100 μm. But significant volume decreases while the electrode pitch increases, i.e. 100 μm to 45 μm. (B) 5 types of 3D structures are proposed, i.e. simple cubic (SC), body-centered cubic (BCC), face-centered cubic (FCC), hexagonal, and tetrahedron. (C) Exploration volume increases in all types of 3D electrode arrays. Note that the linear array (Neuropixels-like) reaches peaks with electrode pitch of 100 μm. (D) Significant volume of all 3D electrode arrays dramatically increases and reaches peaks at electrode pitch of 85-100 um but decreases afterwards. Note that the linear array (Neuropixels-like) reaches the peak at electrode pitch of 45 μm.
    Figure Legend Snippet: Illustration of exploration volume and significant volume in various 3D electrode arrays. (A) Illustration of the concept of exploration volume and significant volume with a simple cubic electrode array. For better illustration, the electrode array in 3D is projected to 2D. Black dots indicate electrodes, and black squares indicate electrodes, with their sensing radius of signals, i.e. 75 μm, in light blue. Union of light blue area and darker blue is defined as exploration volume. Intersection area with at least from 4 depicted in dark blue, which is defined as significant volume. Exporation volume increases while the electrode pitch increases, i.e. 45 μm to 100 μm. But significant volume decreases while the electrode pitch increases, i.e. 100 μm to 45 μm. (B) 5 types of 3D structures are proposed, i.e. simple cubic (SC), body-centered cubic (BCC), face-centered cubic (FCC), hexagonal, and tetrahedron. (C) Exploration volume increases in all types of 3D electrode arrays. Note that the linear array (Neuropixels-like) reaches peaks with electrode pitch of 100 μm. (D) Significant volume of all 3D electrode arrays dramatically increases and reaches peaks at electrode pitch of 85-100 um but decreases afterwards. Note that the linear array (Neuropixels-like) reaches the peak at electrode pitch of 45 μm.

    Techniques Used:

    Simulated distribution of 1000 neurons network in a barrel column with 6 layers. (A) and 384-channel 2D linear electrode array (B1) and 384-channel 3D simple cubic electrode arrays (B2). (C) Increase the noise level by injecting white noise. From top to lower, signal-to-noise ratio of 1, 2, 5, 10, 20, 40, and non-injected raw data.
    Figure Legend Snippet: Simulated distribution of 1000 neurons network in a barrel column with 6 layers. (A) and 384-channel 2D linear electrode array (B1) and 384-channel 3D simple cubic electrode arrays (B2). (C) Increase the noise level by injecting white noise. From top to lower, signal-to-noise ratio of 1, 2, 5, 10, 20, 40, and non-injected raw data.

    Techniques Used: Injection

    Related Articles

    Injection:

    Article Title: Real-time spike sorting with 3D neural probe and triangulation localization
    Article Snippet: Although 3D silicon probes by stacking 2D probes have been developed[ – ] and commercialized (Neuronexus, ATLAS Neuroengineering), they cause severe tissue damage and are difficult to insert into the brain and therefore unfortunately are limited in their usage in larger brain regions.



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    Illustration of exploration volume and significant volume in various <t>3D</t> electrode arrays. (A) Illustration of the concept of exploration volume and significant volume with a simple cubic electrode array. For better illustration, the electrode array in 3D is projected <t>to</t> <t>2D.</t> Black dots indicate electrodes, and black squares indicate electrodes, with their sensing radius of signals, i.e. 75 μm, in light blue. Union of light blue area and darker blue is defined as exploration volume. Intersection area with at least from 4 depicted in dark blue, which is defined as significant volume. Exporation volume increases while the electrode pitch increases, i.e. 45 μm to 100 μm. But significant volume decreases while the electrode pitch increases, i.e. 100 μm to 45 μm. (B) 5 types of 3D structures are proposed, i.e. simple cubic (SC), body-centered cubic (BCC), face-centered cubic (FCC), hexagonal, and tetrahedron. (C) Exploration volume increases in all types of 3D electrode arrays. Note that the linear array (Neuropixels-like) reaches peaks with electrode pitch of 100 μm. (D) Significant volume of all 3D electrode arrays dramatically increases and reaches peaks at electrode pitch of 85-100 um but decreases afterwards. Note that the linear array (Neuropixels-like) reaches the peak at electrode pitch of 45 μm.
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    Illustration of exploration volume and significant volume in various <t>3D</t> electrode arrays. (A) Illustration of the concept of exploration volume and significant volume with a simple cubic electrode array. For better illustration, the electrode array in 3D is projected <t>to</t> <t>2D.</t> Black dots indicate electrodes, and black squares indicate electrodes, with their sensing radius of signals, i.e. 75 μm, in light blue. Union of light blue area and darker blue is defined as exploration volume. Intersection area with at least from 4 depicted in dark blue, which is defined as significant volume. Exporation volume increases while the electrode pitch increases, i.e. 45 μm to 100 μm. But significant volume decreases while the electrode pitch increases, i.e. 100 μm to 45 μm. (B) 5 types of 3D structures are proposed, i.e. simple cubic (SC), body-centered cubic (BCC), face-centered cubic (FCC), hexagonal, and tetrahedron. (C) Exploration volume increases in all types of 3D electrode arrays. Note that the linear array (Neuropixels-like) reaches peaks with electrode pitch of 100 μm. (D) Significant volume of all 3D electrode arrays dramatically increases and reaches peaks at electrode pitch of 85-100 um but decreases afterwards. Note that the linear array (Neuropixels-like) reaches the peak at electrode pitch of 45 μm.
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    Image Search Results


    Illustration of exploration volume and significant volume in various 3D electrode arrays. (A) Illustration of the concept of exploration volume and significant volume with a simple cubic electrode array. For better illustration, the electrode array in 3D is projected to 2D. Black dots indicate electrodes, and black squares indicate electrodes, with their sensing radius of signals, i.e. 75 μm, in light blue. Union of light blue area and darker blue is defined as exploration volume. Intersection area with at least from 4 depicted in dark blue, which is defined as significant volume. Exporation volume increases while the electrode pitch increases, i.e. 45 μm to 100 μm. But significant volume decreases while the electrode pitch increases, i.e. 100 μm to 45 μm. (B) 5 types of 3D structures are proposed, i.e. simple cubic (SC), body-centered cubic (BCC), face-centered cubic (FCC), hexagonal, and tetrahedron. (C) Exploration volume increases in all types of 3D electrode arrays. Note that the linear array (Neuropixels-like) reaches peaks with electrode pitch of 100 μm. (D) Significant volume of all 3D electrode arrays dramatically increases and reaches peaks at electrode pitch of 85-100 um but decreases afterwards. Note that the linear array (Neuropixels-like) reaches the peak at electrode pitch of 45 μm.

    Journal: bioRxiv

    Article Title: Real-time spike sorting with 3D neural probe and triangulation localization

    doi: 10.1101/2025.03.30.645752

    Figure Lengend Snippet: Illustration of exploration volume and significant volume in various 3D electrode arrays. (A) Illustration of the concept of exploration volume and significant volume with a simple cubic electrode array. For better illustration, the electrode array in 3D is projected to 2D. Black dots indicate electrodes, and black squares indicate electrodes, with their sensing radius of signals, i.e. 75 μm, in light blue. Union of light blue area and darker blue is defined as exploration volume. Intersection area with at least from 4 depicted in dark blue, which is defined as significant volume. Exporation volume increases while the electrode pitch increases, i.e. 45 μm to 100 μm. But significant volume decreases while the electrode pitch increases, i.e. 100 μm to 45 μm. (B) 5 types of 3D structures are proposed, i.e. simple cubic (SC), body-centered cubic (BCC), face-centered cubic (FCC), hexagonal, and tetrahedron. (C) Exploration volume increases in all types of 3D electrode arrays. Note that the linear array (Neuropixels-like) reaches peaks with electrode pitch of 100 μm. (D) Significant volume of all 3D electrode arrays dramatically increases and reaches peaks at electrode pitch of 85-100 um but decreases afterwards. Note that the linear array (Neuropixels-like) reaches the peak at electrode pitch of 45 μm.

    Article Snippet: Although 3D silicon probes by stacking 2D probes have been developed[ – ] and commercialized (Neuronexus, ATLAS Neuroengineering), they cause severe tissue damage and are difficult to insert into the brain and therefore unfortunately are limited in their usage in larger brain regions.

    Techniques:

    Simulated distribution of 1000 neurons network in a barrel column with 6 layers. (A) and 384-channel 2D linear electrode array (B1) and 384-channel 3D simple cubic electrode arrays (B2). (C) Increase the noise level by injecting white noise. From top to lower, signal-to-noise ratio of 1, 2, 5, 10, 20, 40, and non-injected raw data.

    Journal: bioRxiv

    Article Title: Real-time spike sorting with 3D neural probe and triangulation localization

    doi: 10.1101/2025.03.30.645752

    Figure Lengend Snippet: Simulated distribution of 1000 neurons network in a barrel column with 6 layers. (A) and 384-channel 2D linear electrode array (B1) and 384-channel 3D simple cubic electrode arrays (B2). (C) Increase the noise level by injecting white noise. From top to lower, signal-to-noise ratio of 1, 2, 5, 10, 20, 40, and non-injected raw data.

    Article Snippet: Although 3D silicon probes by stacking 2D probes have been developed[ – ] and commercialized (Neuronexus, ATLAS Neuroengineering), they cause severe tissue damage and are difficult to insert into the brain and therefore unfortunately are limited in their usage in larger brain regions.

    Techniques: Injection

    Illustration of exploration volume and significant volume in various 3D electrode arrays. (A) Illustration of the concept of exploration volume and significant volume with a simple cubic electrode array. For better illustration, the electrode array in 3D is projected to 2D. Black dots indicate electrodes, and black squares indicate electrodes, with their sensing radius of signals, i.e. 75 μm, in light blue. Union of light blue area and darker blue is defined as exploration volume. Intersection area with at least from 4 depicted in dark blue, which is defined as significant volume. Exporation volume increases while the electrode pitch increases, i.e. 45 μm to 100 μm. But significant volume decreases while the electrode pitch increases, i.e. 100 μm to 45 μm. (B) 5 types of 3D structures are proposed, i.e. simple cubic (SC), body-centered cubic (BCC), face-centered cubic (FCC), hexagonal, and tetrahedron. (C) Exploration volume increases in all types of 3D electrode arrays. Note that the linear array (Neuropixels-like) reaches peaks with electrode pitch of 100 μm. (D) Significant volume of all 3D electrode arrays dramatically increases and reaches peaks at electrode pitch of 85-100 um but decreases afterwards. Note that the linear array (Neuropixels-like) reaches the peak at electrode pitch of 45 μm.

    Journal: bioRxiv

    Article Title: Real-time spike sorting with 3D neural probe and triangulation localization

    doi: 10.1101/2025.03.30.645752

    Figure Lengend Snippet: Illustration of exploration volume and significant volume in various 3D electrode arrays. (A) Illustration of the concept of exploration volume and significant volume with a simple cubic electrode array. For better illustration, the electrode array in 3D is projected to 2D. Black dots indicate electrodes, and black squares indicate electrodes, with their sensing radius of signals, i.e. 75 μm, in light blue. Union of light blue area and darker blue is defined as exploration volume. Intersection area with at least from 4 depicted in dark blue, which is defined as significant volume. Exporation volume increases while the electrode pitch increases, i.e. 45 μm to 100 μm. But significant volume decreases while the electrode pitch increases, i.e. 100 μm to 45 μm. (B) 5 types of 3D structures are proposed, i.e. simple cubic (SC), body-centered cubic (BCC), face-centered cubic (FCC), hexagonal, and tetrahedron. (C) Exploration volume increases in all types of 3D electrode arrays. Note that the linear array (Neuropixels-like) reaches peaks with electrode pitch of 100 μm. (D) Significant volume of all 3D electrode arrays dramatically increases and reaches peaks at electrode pitch of 85-100 um but decreases afterwards. Note that the linear array (Neuropixels-like) reaches the peak at electrode pitch of 45 μm.

    Article Snippet: Although 3D silicon probes by stacking 2D probes have been developed[ – ] and commercialized (Neuronexus, ATLAS Neuroengineering), they cause severe tissue damage and are difficult to insert into the brain and therefore unfortunately are limited in their usage in larger brain regions.

    Techniques:

    Simulated distribution of 1000 neurons network in a barrel column with 6 layers. (A) and 384-channel 2D linear electrode array (B1) and 384-channel 3D simple cubic electrode arrays (B2). (C) Increase the noise level by injecting white noise. From top to lower, signal-to-noise ratio of 1, 2, 5, 10, 20, 40, and non-injected raw data.

    Journal: bioRxiv

    Article Title: Real-time spike sorting with 3D neural probe and triangulation localization

    doi: 10.1101/2025.03.30.645752

    Figure Lengend Snippet: Simulated distribution of 1000 neurons network in a barrel column with 6 layers. (A) and 384-channel 2D linear electrode array (B1) and 384-channel 3D simple cubic electrode arrays (B2). (C) Increase the noise level by injecting white noise. From top to lower, signal-to-noise ratio of 1, 2, 5, 10, 20, 40, and non-injected raw data.

    Article Snippet: Although 3D silicon probes by stacking 2D probes have been developed[ – ] and commercialized (Neuronexus, ATLAS Neuroengineering), they cause severe tissue damage and are difficult to insert into the brain and therefore unfortunately are limited in their usage in larger brain regions.

    Techniques: Injection